This e-Seminar will focus on the theme of comprehensive multifile searching of patent sequence data, using GENESEQ (DGENE), USGENE, PCTGEN and REGISTRY databases on STN. The session will provide a variety of practical tips, from preparing the query through to post-processing search results into a final report using STN Express. A review of the latest DGENE, USGENE and PCTGEN database content enhancement news will also be presented.